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Saccharomyces cerevisiae has been a great model to unravel the transcriptional response to varying iron concentrations and iron uptake strategies, and both processes have been key for understanding the conserved mechanisms shared by other eukaryotes as well as for modelling human fungal pathogens, which are a severe threat to a significant part of the population

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[65,66] In microtubule associated protein Tau (MAPT) P301S PS19 mouse model of tau-dependent neurodegeneration with INK-ATTAC transgene, elimination of p16Ink4a-expressing glial cells, alleviated gliosis, prevented tau hyperphosphorylation and aggregation, hippocampal neuron degeneration and improved cognitive function