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However, they also showed that GPIs and GPI-anchored mucins could activate p38 MAPK later than ERK1/2, thus increasing IL-12 synthesis and generating an opposing effect in the regulation of the immune response by promoting a Th1 response (Ropert et al., 2001)

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PTT (photothermal therapy) employs light-induced hyperthermia to destroy the target tumor cells, as a new approach in cancer therapy (Liang et al., 2016