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This study was based on the mouse CT26 cell line and a nude mouse model and did not include human colorectal cancer cells or clinical samples for validation

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Simultaneously, skeletal muscle in the elderly demonstrates mitochondrial dysfunction, encompassing diminished mitochondrial biogenesis, compromised oxidative phosphorylation, and an augmented production of reactive oxygen species (ROS), which further intensify endothelial oxidative damage and inflammatory responses (21, 22)