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ISL induces apoptosis and autophagy in hepatocellular carcinoma via downregulation of PI3K/AKT/mTOR pathway in vivo and in vitro

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This view is reminiscent of the Warburg hypothesis, in which heightened glycolysis observed in cancer cells is thought to allow for rapid tumor cell proliferation, particularly under limiting oxygen tension ( Fatty acid oxidation In resting T cells that circulate in the periphery, FAO is the default metabolic state, and the metabolism of these quiescent cells is characterized by a need for basal energy utilization over macromolecular biosynthesis ( While an increase in glycolysis generally is observed in activated T cells, this is not always the case